Misty ( m) affects growth traits.
نویسندگان
چکیده
The misty ( m) coat color mutation is commonly maintained in linkage disequilibrium with the obesity mutation diabetes ( Leprdb ) to serve as a marker for Leprdb genotype. Comparisons among Leprdb genotypes are made under the untested assumption that m has no effects on traits under investigation. We tested this assumption in a population segregating m in the absence of db. Analysis of growth curves revealed that m/m mice are smaller than M/M mice by the 2nd wk of life and remain smaller through the 5th wk of life. Analysis of variance of three traits measured at 35 days of age revealed that m/m mice are 8% shorter than M/M mice, weigh 15% less, and have 21% less inguinal adipose mass. These results indicate that m affects growth traits. Therefore, when m and Leprdb segregate in the same cross, interpretation of their effects is confounded by linkage. More accurate estimates of Leprdb genotype effects can be made by removing m from populations segregating Leprdb and using a direct assay to measure Leprdb genotype.
منابع مشابه
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ورودعنوان ژورنال:
- The American journal of physiology
دوره 275 1 Pt 2 شماره
صفحات -
تاریخ انتشار 1998